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[Number]

Heinrich Luitpold Himmler (German: [ˈhaɪnʁɪç ˈluːɪtˌpɔlt ˈhɪmlɐ] (About this soundlisten); 7 October 1900 – 23 May 1945) was Reichsführer of the Schutzstaffel (Protection Squadron; SS), and a leading member of the Nazi Party (NSDAP) of Germany. Himmler was one of the most powerful men in Nazi Germany and a main architect of the Holocaust.

As a member of a reserve battalion during World War I, Himmler did not see active service. He studied agronomy in university, and joined the Nazi Party in 1923 and the SS in 1925. In 1929, he was appointed Reichsführer-SS by Adolf Hitler. Over the next 16 years, he developed the SS from a mere 290-man battalion into a million-strong paramilitary group, and, following Hitler's orders, set up and controlled the Nazi concentration camps. He was known for good organisational skills and for selecting highly competent subordinates, such as Reinhard Heydrich in 1931. From 1943 onwards, he was both Chief of German Police and Minister of the Interior, overseeing all internal and external police and security forces, including the Gestapo (Secret State Police). Himmler had a lifelong interest in occultism, interpreting Germanic neopagan and Völkisch beliefs to promote the racial policy of Nazi Germany, and incorporating esoteric symbolism and rituals into the SS.

On Hitler's behalf, Himmler formed the Einsatzgruppen and built extermination camps. As facilitator and overseer of the concentration camps, Himmler directed the killing of some six million Jews, between 200,000 and 500,000 Romani people, and other victims; the total number of civilians killed by the regime is estimated at eleven to fourteen million people. Most of them were Polish and Soviet citizens.

Late in World War II, Hitler briefly appointed him a military commander and later Commander of the Replacement (Home) Army and General Plenipotentiary for the administration of the entire Third Reich (Generalbevollmächtigter für die Verwaltung). Specifically, he was given command of the Army Group Upper Rhine and the Army Group Vistula; he failed to achieve his assigned objectives and Hitler replaced him in these posts. Realising the war was lost, Himmler attempted to open peace talks with the western Allies without Hitler's knowledge, shortly before the end of the war. Hearing of this, Hitler dismissed him from all his posts in April 1945 and ordered his arrest. Himmler attempted to go into hiding, but was detained and then arrested by British forces once his identity became known. While in British custody, he committed suicide on 23 May 1945.

[Tuksi]

Gordale Scar is a limestone ravine 1 mile (1.6 km) northeast of Malham, North Yorkshire, England.[1] It contains two waterfalls and has overhanging limestone cliffs over 100 metres high. The gorge could have been formed by water from melting glaciers or a cavern collapse. The stream flowing through the scar is Gordale Beck, which on leaving the gorge flows over Janet's Foss before joining Malham Beck two miles downstream to form the River Aire.[2] A right of way leads up the gorge, but requires climbing approximately 10 feet of tufa at the lower waterfall.

[Number]

Mariscal Sucre International Airport[3] (Spanish: Aeropuerto Internacional Mariscal Sucre) (IATA: UIO, ICAO: SEQM) is the busiest airport in Ecuador and one of the busiest airports in South America. It is located in the Tababela parish, about 18 kilometres (11 mi)[4] east of Quito and serves as the largest hub of TAME, the flag carrier of Ecuador, with an average of over 220 weekly flights. It opened in February 2013 and replaced the old Mariscal Sucre International Airport.[5] The airport is named after independence leader Antonio José de Sucre.

[Tuksi]

Moda Center, formerly known as the Rose Garden, is the primary indoor sports arena in Portland, Oregon, United States. It is used for basketball, ice hockey, rodeos, circuses, conventions, ice shows, concerts, and dramatic productions. The arena has a capacity of 19,393 spectators when configured for basketball.[2] It is equipped with state-of-the-art acoustics and other amenities.[8]

The arena is owned by Vulcan Inc., a holding company owned by the estate of Paul Allen, and is currently managed by Anschutz Entertainment Group and AEG Live. The primary tenant is the Portland Trail Blazers NBA franchise, also owned by Allen. The other major tenant of the building today is the major junior hockey franchise Portland Winterhawks of the Western Hockey League, which splits its schedule with the Memorial Coliseum next door. In addition to the Blazers and Winterhawks, several other professional sports franchises, and the Portland State University men's basketball team, either currently play home games in Moda Center, or have done so in the past. In addition, Moda Center is a popular venue for concerts and other artistic productions.[9]

Construction began in 1993, and the arena opened on October 12, 1995. The arena cost US$262 million to build; construction was financed with funds obtained by a variety of sources, including the City of Portland, Allen's personal fortune, and $155 million in bonds issued by a consortium of mutual funds and insurance companies.[10] These bonds would become the subject of an acrimonious 2004 bankruptcy in which the Oregon Arena Corporation, the holding company which owned the arena at the time, would forfeit title to the arena in lieu of repaying the bonds per the payment terms.[11] Allen would later repurchase the arena from the creditors in 2007.[12]

[Number]

Portland (/ˈpɔːrtlənd/; PORT-lənd) is the largest and most populous city in the U.S. state of Oregon and the seat of Multnomah County. It is a major port in the Willamette Valley region of the Pacific Northwest, at the confluence of the Willamette and Columbia rivers. As of 2018, Portland had an estimated population of 653,115,[7] making it the 25th most populated city in the United States, and the second-most populous in the Pacific Northwest after Seattle.[9] Approximately 2.4 million people live in the Portland metropolitan statistical area (MSA), making it the 25th most populous in the United States. Its combined statistical area (CSA) ranks 19th-largest with a population of around 3.2 million. Approximately 60% of Oregon's population resides within the Portland metropolitan area.[a]

Named after Portland, Maine,[10] the Oregon settlement began to be populated in the 1830s near the end of the Oregon Trail. Its water access provided convenient transportation of goods, and the timber industry was a major force in the city's early economy. At the turn of the 20th century, the city had a reputation as one of the most dangerous port cities in the world, a hub for organized crime and racketeering. After the city's economy experienced an industrial boom during World War II, its hard-edged reputation began to dissipate. Beginning in the 1960s,[11] Portland became noted for its growing progressive political values, earning it a reputation as a bastion of counterculture.[12]

The city operates with a commission-based government guided by a mayor and four commissioners as well as Metro, the only directly elected metropolitan planning organization in the United States.[13] The city government is notable for its land-use planning and investment in public transportation.[14] Portland is frequently recognized as one of the world's most environmentally conscious cities because of its high walkability, large community of bicyclists, farm-to-table dining, expansive network of public transportation options, and over 10,000 acres (4,000 hectares) of public parks. As a result, Portland consistently ranks highly in quality of life in the United States.[15] Its climate is marked by warm, dry summers and cool, rainy winters. This climate is ideal for growing roses, and Portland has been called the "City of Roses" for over a century.[16]

[Tuksi]

Colorado Mining District was primarily a silver and gold mining district organized in El Dorado Canyon, New Mexico Territory on the west shore of the Colorado River in what is now Clark County, Nevada. The Colorado District was part of Arizona Territory from 1863 to 1869. In 1869, the land of Arizona Territory north and west of the Colorado River east to the 114th meridian of longitude, including the Colorado District, was turned over to Nevada.

History
The Colorado District had been organized by at least June 1, 1862. At a District meeting organized on January 8, 1863, officers were elected including a Mr. Lewis to fill an unexpired term as recorder that had begun on June 1, 1862. [1] There were 611 locations recorded at the end of 1863.[2]:400

El Dorado City was the site of the El Dorado Mills or Colorado Mills, first stamp mill in the canyon, at the mouth of January Wash at its confluence with El Dorado Canyon, about a mile down the canyon from Huse Spring. [3] Its site was located nearby to the south southeast of the Techatticup Mine the primary source of the ore its mill processed. In late 1863, the mill made with parts of abandoned or closed mills brought in from California was completed. Col. James Russell Vineyard at the time a State Senator from Los Angeles began the mill, to process the ore of the district mines cut out the cost of shipping the ore down the Colorado River by steamboat, and by sea to San Francisco for processing, thus cutting costs in half for those mine owners.[4] :33,35

[Number]

The Colorado Avalanche are a professional ice hockey team based in Denver, Colorado. They are members of the Central Division of the Western Conference of the National Hockey League (NHL). The Avalanche are the only team in their division not based in the Central Time Zone; the team is situated in the Mountain Time Zone. Their home arena is Pepsi Center, which they share with the Denver Nuggets of the National Basketball Association. Their general manager is Joe Sakic.

The Avalanche were founded in 1972 as the Quebec Nordiques and were one of the charter franchises of the World Hockey Association. The franchise joined the NHL in 1979 as a result of the NHL–WHA merger. Following the 1994–95 season, they were sold to the COMSAT Entertainment Group and relocated to Denver.

In the club's first season in Denver, the Avalanche won the Pacific Division and went on to sweep the Florida Panthers in the 1996 Stanley Cup Finals, becoming the first NHL team to win the Stanley Cup in the season following a relocation. Among teams in the major North American professional sports leagues, only the National Football League (NFL)'s Washington Redskins have also accomplished the feat. This was the first major professional sports championship a Denver-based team brought to the city.

In the 2001 Stanley Cup Finals, the Avalanche defeated the New Jersey Devils 4–3 to win their second and most recent championship. As a result, they are the only active NHL team that has won all of its Stanley Cup Final appearances.

The Avalanche have won nine division titles (including their first eight in a row in Denver, the longest such streak in NHL history) and qualified for the playoffs in each of their first ten seasons in Denver; this streak ended in 2007.[4]

[Tuksi]

Tyrosine hydroxylase or tyrosine 3-monooxygenase is the enzyme responsible for catalyzing the conversion of the amino acid L-tyrosine to L-3,4-dihydroxyphenylalanine (L-DOPA).[5][6] It does so using molecular oxygen (O2), as well as iron (Fe2+) and tetrahydrobiopterin as cofactors. L-DOPA is a precursor for dopamine, which, in turn, is a precursor for the important neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline). Tyrosine hydroxylase catalyzes the rate limiting step in this synthesis of catecholamines. In humans, tyrosine hydroxylase is encoded by the TH gene,[6] and the enzyme is present in the central nervous system (CNS), peripheral sympathetic neurons and the adrenal medulla.[6] Tyrosine hydroxylase, phenylalanine hydroxylase and tryptophan hydroxylase together make up the family of aromatic amino acid hydroxylases (AAAHs).Reaction
tyrosine 3-monooxygenase
Tyrosine to L-DOPA reaction TH.svg
Tyrosine hydroxylase catalyzes conversion of tyrosine to L-DOPA using Fe2+, O2 and BH4
Identifiers
EC number 1.14.16.2
CAS number 9036-22-0
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO
Search
Tyrosine hydroxylase catalyzes the reaction in which L-tyrosine is hydroxylated in the meta position to obtain L-3,4-dihydroxyphenylalanine (L-DOPA). The enzyme is an oxygenase which means it uses molecular oxygen to hydroxylate its substrates. One of the oxygen atoms in O2 is used to hydroxylate the tyrosine molecule to obtain L-DOPA and the other one is used to hydroxylate the cofactor. Like the other aromatic amino acid hydroxylases (AAAHs), tyrosine hydroxylase use the cofactor tetrahydrobiopterin (BH4) under normal conditions, although other similar molecules may also work as a cofactor for tyrosine hydroxylase.[7]

The AAAHs converts the cofactor 5,6,7,8-tetrahydrobiopterin (BH4) into tetrahydrobiopterin-4a-carbinolamine (4a-BH4). Under physiological conditions, 4a-BH4 is dehydrated to quinonoid-dihydrobiopterin (q-BH2) by the enzyme pterin-4a-carbinolamine dehydrase (PCD) and a water molecule is released in this reaction.[8][9] Then, the NAD(P)H dependent enzyme dihydropteridine reductase (DHPR) converts q-BH2 back to BH4.[8] Each of the four subunits in tyrosine hydroxylase is coordinated with an iron(II) atom presented in the active site. The oxidation state of this iron atom is important for the catalytic turnover in the enzymatic reaction. If the iron is oxidized to Fe(III), the enzyme is inactivated.[10]

[Number]

The Nokia 3310 is a GSM mobile phone announced on 1 September 2000,[2] and released in the fourth quarter of the year, replacing the popular Nokia 3210. It sold very well, being one of the most successful phones with 126 million units sold worldwide,[3] and being one of Nokia's most iconic devices. The phone is still widely acclaimed[1] and has gained a cult status due to its durability.

Several variants of the 3310 have been released, including the Nokia 3315, 3320, 3330, 3350, 3360, 3390 and 3395.

The Nokia 3310 was produced at factories in Finland and Hungary. The 3315s were produced in South Korea for the Asia-Pacific market.

A new mobile phone based on the iconic 3310 design was launched in 2017. The new Nokia 3310 model comes with a comprehensive update over its predecessor with a 2.4" colour display, a 2MP rear camera and a microSD slot.[4]

[Tuksi]

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