Agressive drinks your health! <3

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Gluten-related disorders is the term for the diseases triggered by gluten, including celiac disease (CD), non-celiac gluten sensitivity (NCGS), gluten ataxia, dermatitis herpetiformis (DH) and wheat allergy.[1][2] The umbrella category has also been referred to as gluten intolerance, though a multi-disciplinary physician-led study, based in part on the 2011 International Coeliac Disease Symposium, concluded that the use of this term should be avoided due to a lack of specificity.[1]

Gluten is a group of proteins, such as prolamins and glutelins[3], stored with starch in the endosperm of various cereal (grass) grains.

As of 2017, gluten-related disorders were increasing in frequency in different geographic areas. The increase might be explained by the popularity of the Western diet, the expanded reach of the Mediterranean diet (which also includes grains with gluten), the growing replacement of rice by wheat in many countries,[4] the development in recent years of new types of wheat with a higher amount of cytotoxic gluten peptides,[5] and the higher content of gluten in bread and bakery products, due to the reduction of dough fermentation time.[5]

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Prague (/prɑːɡ/; Czech: Praha [ˈpraɦa] (About this soundlisten), German: Prag, Latin: Praga) is the capital and largest city in the Czech Republic, the 14th largest city in the European Union[9] and the historical capital of Bohemia. Situated on the Vltava river, Prague is home to about 1.3 million people, while its metropolitan area is estimated to have a population of 2.6 million.[4] The city has a temperate oceanic climate, with relatively warm summers and chilly winters.

Prague is a political, cultural and economic centre of central Europe complete with a rich history. Founded during the Romanesque and flourishing by the Gothic, Renaissance and Baroque eras, Prague was the capital of the Kingdom of Bohemia and the main residence of several Holy Roman Emperors, most notably of Charles IV (r. 1346–1378).[10] It was an important city to the Habsburg Monarchy and its Austro-Hungarian Empire. The city played major roles in the Bohemian and Protestant Reformation, the Thirty Years' War and in 20th-century history as the capital of Czechoslovakia between the World Wars and the post-war Communist era.[11]

Prague is home to a number of well-known cultural attractions, many of which survived the violence and destruction of 20th-century Europe. Main attractions include Prague Castle, Charles Bridge, Old Town Square with the Prague astronomical clock, the Jewish Quarter, Petřín hill and Vyšehrad. Since 1992, the extensive historic centre of Prague has been included in the UNESCO list of World Heritage Sites.

The city has more than ten major museums, along with numerous theatres, galleries, cinemas and other historical exhibits. An extensive modern public transportation system connects the city. It is home to a wide range of public and private schools, including Charles University in Prague, the oldest university in Central Europe.[12]

Prague is classified as an "Alpha −" global city according to GaWC studies[13] and ranked sixth in the Tripadvisor world list of best destinations in 2016.[14] In 2019, the city was ranked as 69th most liveable city in the world by Mercer.[15] In the same year, the PISCA Index ranked the city as 13th most liveable city in the world.[16] Its rich history makes it a popular tourist destination and as of 2017, the city receives more than 8.5 million international visitors annually. In 2017 Prague was listed as the fifth most visited European city after London, Paris, Rome and Istanbul.[17]

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Aristarchus (/ˌærəˈstɑːrkəs/; Greek: Ἀρίσταρχος, Aristarkhos) was a ruler of Colchis as a client of Rome from 63 BC to c. 50 BC. He was installed by the Roman general Pompey as part of his settlement of Asia during the Mithridatic Wars. Aristarchus is principally known from the works of the 1st-century historian Appian as well as the coinage issued in his name.

Biographical notes
Aristarchus was appointed, in 63 BC, by Pompey on his conquest of Colchis, a region on the Black Sea, in the course of the Third Mithridatic War which pitted Rome against Mithridates VI of Pontus. Aristarchus's becoming "a dynast of the Colchians" is reported by Appian. The fact of appointment of a new ruler in Colchis is also known to Strabo, but he does not specify the dynast's name. As Aristarchus's extant drachms confirm he was "over Colchis", but he was not a king despite being so called by the 4th-century historian Eutropius.[2][3]

Aristarchus was probably one of the local aristocrats, skeptouchoi ("sceptre-bearers"), who chose to side with the Romans during the war with Mithridates. The only other skeptouchos known by name, Olthaces, was made prisoner by Pompey and paraded in the streets of Rome as part of his triumphal procession. The extent of Aristarchus's possessions is not known. He could have sat at Phasis, at modern Poti, the end-point of Pompey's Colchian campaign, or Dioscurias, an important Hellenistic city, probably near modern-day Sukhumi, where one of his coins has been found. The year 12 on Aristarchus's coinage indicates that his rule in Colchis continued to at least 52 or 51 BC and probably later, until c. 47 BC, when the late king Mithridates's son, Pharnaces II, took advantage of a civil war in Rome and conquered Colchis.[2][3]

Coinage
Of the six extant silver coins issued in the name of Aristarchus, one is located at the British Museum, Berlin, and Paris, two in the Hermitage Museum, and one, unpublished, at Oxford's Ashmolean Museum. The find-spot of only one of the Hermitage examples is known, near Sukhumi.[3] The obverse depicts a male head in a radiant crown, presumably Helios, but resembling Pompey. In the view of the Georgian numismatist Dundua, this depiction marries the traditional claim of the kings of Colchis to be descended from the sun-god to a political necessity to recognize Pompey as the source of Aristarchus's power.[2][4] The seated female figure wearing a mural crown on the reverse is probably Tyche, a deity that governed the fortune and prosperity of a city, accompanied by the legend ΑΡΙΣΤΑΡΧΟ(Υ) ΤΟΥ ΕΠΙ ΚΟΛΧΙΔΟ(Σ).[2][3]

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Dawson City, officially the Town of the City of Dawson, is a town in the Canadian territory of Yukon. It is inseparably linked to the Klondike Gold Rush (1896–99). Its population was 1,375 as of the 2016 census,[2] making it the second largest town of Yukon.

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Dame Elsie Payne (1927–2004) was a teacher and the first indigenous Barbadian to serve as principal of Queen's College of Bridgetown. She was the first woman knighted in Barbados for her long dedication to education and the nation.Early life
Elsie Pilgrim was born on 14 May 1927 in Bridgetown, Saint Michael Parish, Barbados to S.O. Pilgrim, a shoe merchant in Bridgetown.[1][2] Her ancestry included Charles Pilgrim, who was at one time the headmaster of Combermere School. Pilgrim entered Queen's College at the age of nine and continued to her graduation.[1] In 1946, Pilgrim won the Barbados Government Scholarship,[3] the first time the scholarship had been awarded to a woman. She continued her university studies at Exeter College, then a part of the University of London, earning a Bachelor of Arts in history in 1949. Furthering her education, Pilgrim then enrolled at the University of Cambridge, attaining a PhD in history.[1]

Career
Pilgrim returned to Barbados and began her teaching career at Queen's College in 1952 and the following year married Dr. David O. Payne.[2] She was known as an excellent teacher and in a time when the history of the British West Indies was not typically a part of the curriculum, Payne taught about slavery in the Caribbean.[1] In 1966, Payne was appointed as deputy headmistress of Queen's College.[4] When Barbadian teachers struck in 1969, over a salary and working conditions dispute with the Ministry of Education, Payne became the spokesman for the teachers and the Barbados Secondary Teachers' Union.[5] The nature of the conflict was that teachers who had been appointed to the staff of the newly opened Barbados Community College were offered different salaries and conditions than teachers who were equally qualified and were employed in secondary schools. The dispute became heated, with threats of firing, loss of pension and other benefits from Prime Minister Errol Barrow. Payne and the teachers stood resolute and gained the concessions for which they fought,[6] resulting in an overhaul and reform of Barbados' educational system.[5]
In 1970, Payne became the first Barbadian-born principal of the school[4] and the following year was one of the founders of the Parent-Teacher Association. In addition to her work at Queen's College, Payne served on several national education boards,[1] the Barbados Constitution Review Commission, the Barbados Privy Council,[7] as well as providing lectures at the Centre for Multi-Racial Studies under the auspices of the University of the West Indies and the University of Sussex.[8] Serving on the Council of the University of the West Indies from 1973,[9] she served as the Council Chair in 1987.[10] For her many contributions to education and the nation, Payne was knighted in 1980, becoming the first woman honoured by the Order of St. Andrew.[7][11] She continued leading Queen's College until her retirement in 1985.[7]
Death and legacy
Payne died on 25 August 2004 in Bridgetown, Barbados.[7] The buildings of Queen's College were renamed to honour the four indigenous female principals in 2007, including one named after Payne.[12] In addition, the headquarters of the Ministry of Education are named in her honour, as is a roundabout near the Bridgetown Port.[1] In 2016, Payne was honoured as one of Barbados' best public officers and included in a special publication Challenge to Change issued by the Office of Public Sector Reform.[13]

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The Hangover is a 2009 American comedy film directed by Todd Phillips, co-produced with Daniel Goldberg,[not verified in body] and written by Jon Lucas and Scott Moore. It is the first installment in The Hangover trilogy. The film stars Bradley Cooper, Ed Helms, Zach Galifianakis, Heather Graham, Justin Bartha, Ken Jeong, and Jeffrey Tambor. It tells the story of Phil Wenneck, Stu Price, Alan Garner, and Doug Billings, who travel to Las Vegas for a bachelor party to celebrate Doug's impending marriage. However, Phil, Stu, and Alan wake up with Doug missing and no memory of the previous night's events, and must find the groom before the wedding can take place.

Lucas and Moore wrote the script after executive producer Chris Bender's friend disappeared and had a large bill after being sent to a strip club. After Lucas and Moore sold it to the studio for $2 million, Philips and Jeremy Garelick rewrote the script to include a tiger as well as a subplot involving a baby and a police cruiser, and also including boxer Mike Tyson. Filming took place in Nevada for 15 days, and during filming, the three main actors (Cooper, Helms, and Galifianakis) formed a real friendship.

The Hangover was released on June 5, 2009,[4] and was a critical and commercial success. The film became the tenth-highest-grossing film of 2009, with a worldwide gross of over $467 million. The film won the Golden Globe Award for Best Motion Picture – Musical or Comedy, and received multiple other accolades. It is the tenth-highest-grossing worldwide film of 2009, as well as the second-highest-grossing R-rated comedy ever in the United States, surpassing a record previously held by Beverly Hills Cop for almost 25 years.[5]

A sequel, The Hangover Part II, was released on May 26, 2011, and a third and final installment, The Hangover Part III, was released on May 23, 2013.

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